She made her cinematic debut with Rehnaa Hai Terre Dil Mein opposite R. Madhavan. The film was not a box office success. A series of unsuccessful films followed, among them Tumsa Nahin Dekha and Deewaanapan. In 2005, Mirza appeared in Parineeta, a Vidhu Vinod Chopra production. In 2006 she teamed up once again with Chopra and Sanjay Dutt for the successful film Lage Raho Munna Bhai. She also played in the music video Kajara Mohabbat Wala from Sonu Nigam album Kajara Nite.[6] She has also appeared in Dus and in Fight Club. She will appear later this year in Familywala and Naa Naa Karte